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I was given benzodiazepines, opiates and cocaine: bascially a speed ball? The result was that I didn't get a trip to lazy la-la land like I thought I would. I was VERY AWAKE and RATHER FRFEAKED OUT the whole time. I wrote out a point format version of the history of english lit in the recovery room, and also stripped the bed. I neatly re-folded the sheets and put them on the railing of the stretcher. It is one thing to have to be awake when the are pulling bones out through your nose, it is another thing to be in a heightened state of alertness. I highly recommend a general anesthetic...
Cocaine is readily absorbed from all mucous membranes. Although cocaine's local vasoconstrictive effect may limit to some extent its rate of absorption (measurable quantities have been reported to remain in the nasal mucosa for 3 hours after application), the rate of absorption may exceed the rate of metabolism and/or excretion, leading to a significant risk of systemic toxicity. Entry of cocaine into the brain may be especially rapid following application to the nasal mucosa, particularly if the medication is applied as a fine-mist spray. Also, cocaine is more readily absorbed from inflamed or damaged tissue.
Note:
Many of cocaine's systemic adverse effects are due to excessive sympathetic activity and may be caused by rapid absorption, decreased patient tolerance, or, rarely, hypersensitivity. Toxic reactions are relatively uncommon with appropriate use of usual clinical doses.
The fatal dose of cocaine has been reported to be 1.2 grams. However, patient sensitivity to the effects of the medication is highly variable; adverse effects have been reported with as little as 20 mg.
Acute toxicity may occur very rapidly. Manifestations of systemic cocaine toxicity may occur in 3 stages (early stimulation, advanced stimulation, and depression). Although many of the signs and symptoms of early stimulation would not necessarily require medical intervention under other circumstances, their occurrence following use of cocaine indicates that prompt action is required, because progression from one stage of toxicity to the next may be very rapid.
The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)—not necessarily inclusive:
Those indicating need for medical attention
Signs and symptoms of systemic toxicity
Early stimulation Cardiac/cardiovascular effects, including increased blood pressure increased heart rate premature ventricular contractions (irregular heartbeat) vasoconstriction chills and fever CNS effects, including agitation excitement nervousness restlessness apprehension irritability confusion dizziness or lightheadedness hallucinations sudden headache inability to remain still mood or mental changes, including elation or euphoria dysphoria or dysphoric agitation paranoid ideation or psychosis preconvulsive movements talkativeness generalized tics or twitching of small muscles —especially of the face, fingers, or feet gastrointestinal effects, including abdominal pain nausea or vomiting grinding of teeth increased sweating rapid breathing unusually large pupils —sometimes with bulging of eyes
Note:
Hallucinations may be auditory, gustatory, olfactory, visual (e.g., ``snow lights''), and/or tactile (e.g., formication [``cocaine bugs''], which may induce picking or stroking movements).
Tachycardia occurring after low doses of cocaine may initially be preceded by bradycardia
from:
http://www.pharmgkb.org/do/serve?objId=151&objCls=DrugProperties
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